| UFC Fight Night: Lewis vs. Nascimento | Derrick Lewis | 1101 →1121(+20) | Rodrigo Nascimento | 1061 →1041(-20) | Heavyweight | Win | KO |
| UFC Fight Night: Almeida vs. Lewis | Jailton Almeida | 1109 →1129(+20) | Derrick Lewis | 1122 →1101(-21) | Heavyweight | Loss | U-DEC |
| UFC 291: Poirier vs. Gaethje 2 | Derrick Lewis | 1100 →1122(+22) | Marcos Rogerio de Lima | 1079 →1057(-22) | Heavyweight | Win | KO |
| UFC Fight Night: Lewis vs. Spivac | Serghei Spivac | 1068 →1095(+27) | Derrick Lewis | 1127 →1100(-27) | Heavyweight | Loss | SUB |
| UFC 277: Pena vs. Nunes 2 | Sergei Pavlovich | 1054 →1083(+29) | Derrick Lewis | 1157 →1127(-30) | Heavyweight | Loss | KO |
| UFC 271: Adesanya vs. Whittaker 2 | Tai Tuivasa | 1089 →1118(+29) | Derrick Lewis | 1186 →1157(-29) | Heavyweight | Loss | KO |
| UFC Fight Night: Lewis vs. Daukaus | Derrick Lewis | 1168 →1186(+18) | Chris Daukaus | 1091 →1073(-18) | Heavyweight | Win | KO |
UFC 265: Lewis vs. Gane | Ciryl Gane | 1130 →1157(+27) | Derrick Lewis | 1195 →1168(-27) | Heavyweight | Loss | KO |
| UFC Fight Night: Blaydes vs. Lewis | Derrick Lewis | 1173 →1195(+22) | Curtis Blaydes | 1157 →1135(-22) | Heavyweight | Win | KO |
| UFC Fight Night: Lewis vs. Oleinik | Derrick Lewis | 1155 →1173(+18) | Aleksei Oleinik | 1084 →1066(-18) | Heavyweight | Win | KO |
| UFC 247: Jones vs. Reyes | Derrick Lewis | 1140 →1155(+15) | Ilir Latifi | 1045 →1031(-14) | Heavyweight | Win | U-DEC |
| UFC 244: Masvidal vs. Diaz | Derrick Lewis | 1125 →1140(+15) | Blagoy Ivanov | 1034 →1019(-15) | Heavyweight | Win | S-DEC |
| UFC Fight Night: Lewis vs. Dos Santos | Junior Dos Santos | 1168 →1190(+22) | Derrick Lewis | 1147 →1125(-22) | Heavyweight | Loss | KO |
| UFC 230: Cormier vs. Lewis | Daniel Cormier | 1217 →1237(+20) | Derrick Lewis | 1167 →1147(-20) | Heavyweight | Loss | SUB |
| UFC 229: Khabib vs. McGregor | Derrick Lewis | 1147 →1167(+20) | Alexander Volkov | 1097 →1077(-20) | Heavyweight | Win | KO |
| UFC 226: Miocic vs. Cormier | Derrick Lewis | 1128 →1147(+19) | Francis Ngannou | 1116 →1096(-20) | Heavyweight | Win | U-DEC |
| UFC Fight Night: Cerrone vs. Medeiros | Derrick Lewis | 1109 →1128(+19) | Marcin Tybura | 1035 →1017(-18) | Heavyweight | Win | KO |
| UFC Fight Night: Lewis vs. Hunt | Mark Hunt | 1062 →1090(+28) | Derrick Lewis | 1137 →1109(-28) | Heavyweight | Loss | KO |
| UFC Fight Night: Lewis vs. Browne | Derrick Lewis | 1117 →1137(+20) | Travis Browne | 1083 →1062(-21) | Heavyweight | Win | KO |
| UFC Fight Night: Lewis vs. Abdurakhimov | Derrick Lewis | 1099 →1117(+18) | Shamil Abdurakhimov | 1016 →998(-18) | Heavyweight | Win | KO |
| UFC Fight Night: Dos Anjos vs. Alvarez | Derrick Lewis | 1082 →1099(+17) | Roy Nelson | 1029 →1012(-17) | Heavyweight | Win | S-DEC |
| UFC Fight Night: Rothwell vs Dos Santos | Derrick Lewis | 1061 →1082(+21) | Gabriel Gonzaga | 1033 →1012(-21) | Heavyweight | Win | KO |
| UFC Fight Night: Hendricks vs Thompson | Derrick Lewis | 1041 →1061(+20) | Damian Grabowski | 1000 →979(-21) | Heavyweight | Win | KO |
| UFC 192: Cormier vs Gustafsson | Derrick Lewis | 1019 →1041(+22) | Viktor Pesta | 1001 →979(-22) | Heavyweight | Win | KO |
| UFC Fight Night: Boetsch vs Henderson | Shawn Jordan | 1051 →1073(+22) | Derrick Lewis | 1041 →1019(-22) | Heavyweight | Loss | KO |
| UFC 184: Rousey vs Zingano | Derrick Lewis | 1023 →1041(+18) | Ruan Potts | 955 →936(-19) | Heavyweight | Win | KO |
| UFC Fight Night: Jacare vs Mousasi | Matt Mitrione | 1069 →1090(+21) | Derrick Lewis | 1044 →1023(-21) | Heavyweight | Loss | KO |
| The Ultimate Fighter: Team Edgar vs. Team Penn Finale | Derrick Lewis | 1023 →1044(+21) | Guto Inocente | 1000 →978(-22) | Heavyweight | Win | KO |
| UFC on FOX: Werdum vs Browne | Derrick Lewis | 1000 →1023(+23) | Jack May | 1000 →977(-23) | Heavyweight | Win | KO |
